University of Pittsburgh


Organ System Pathophysiology


January 23, 2020-February 7, 2020
12 half days

Course Director
Frederick DeRubertis, MD
Department of Medicine

Course Director
Mary Korytkowski, MD
Department of Medicine


Course Description

The contribution of endocrine systems to homeostasis is the focus of this course. It also examines common clinical presentation and treatment of endocrine disease.

The goals of the course are:

  1. to learn the normal structure, function, and organization of the major endocrine systems in the body.
  2. to gain detailed knowledge of the regulation of hormonal secretion from the major glands of the body.
  3. to understand the receptor and post-receptor mechanisms that allow selective expression of hormonal actions at a cellular level.
  4. to become familiar with the etiology, pathophysiology, pathology, diagnosis, treatment, and prognosis of the clinically important disorders of the major endocrine systems of the body.

The 28 faculty are from 6 departments: Cell Biology and Physiology; Medicine (Division of Endocrinology; Ophthalmology; Pathology; Pediatrics; and Surgery.

Educational Methods


Lectures Multidisciplinary workshops Clinical pathological conferences    
Small-group problem-based learning sessions Histopathology laboratory        



Evaluation is based on a single, multiple-choice examination and on attendance and participation in small group exercises.

Grading: This course comprises 17% of the grade for the Organ Systems Pathophysiology Block, Section 3. Grading for the block is Satisfactory or Unsatisfactory.

Faculty Note

James Johnston, MD is a recipient of the Kenneth E. Schuit Master Educator Award. In addition, Dr. Johnston is the director of the UPSOM Academy of Master Educators.